Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence. [electronic resource]
Producer: 20150608Description: 1633-41 p. digitalISSN:- 1476-5403
- Animals
- Carcinoma, Pancreatic Ductal -- pathology
- Cell Line
- Cell Transformation, Neoplastic -- genetics
- Cellular Senescence -- genetics
- Cyclin-Dependent Kinase Inhibitor p27 -- biosynthesis
- DNA-Binding Proteins -- genetics
- Forkhead Box Protein O3
- Forkhead Transcription Factors -- biosynthesis
- Gene Expression Regulation, Neoplastic
- Humans
- Mice
- Mice, Knockout
- Neoplasm Proteins -- genetics
- Pancreatic Neoplasms -- pathology
- Proto-Oncogene Proteins p21(ras) -- biosynthesis
- RNA Interference
- RNA, Small Interfering
- S-Phase Kinase-Associated Proteins -- biosynthesis
- Up-Regulation
- beta-Galactosidase -- biosynthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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