Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence.
Grasso, D
Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence. [electronic resource] - Cell death and differentiation Oct 2014 - 1633-41 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-5403
10.1038/cdd.2014.74 doi
Animals
Carcinoma, Pancreatic Ductal--pathology
Cell Line
Cell Transformation, Neoplastic--genetics
Cellular Senescence--genetics
Cyclin-Dependent Kinase Inhibitor p27--biosynthesis
DNA-Binding Proteins--genetics
Forkhead Box Protein O3
Forkhead Transcription Factors--biosynthesis
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Knockout
Neoplasm Proteins--genetics
Pancreatic Neoplasms--pathology
Proto-Oncogene Proteins p21(ras)--biosynthesis
RNA Interference
RNA, Small Interfering
S-Phase Kinase-Associated Proteins--biosynthesis
Up-Regulation
beta-Galactosidase--biosynthesis
Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence. [electronic resource] - Cell death and differentiation Oct 2014 - 1633-41 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-5403
10.1038/cdd.2014.74 doi
Animals
Carcinoma, Pancreatic Ductal--pathology
Cell Line
Cell Transformation, Neoplastic--genetics
Cellular Senescence--genetics
Cyclin-Dependent Kinase Inhibitor p27--biosynthesis
DNA-Binding Proteins--genetics
Forkhead Box Protein O3
Forkhead Transcription Factors--biosynthesis
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Knockout
Neoplasm Proteins--genetics
Pancreatic Neoplasms--pathology
Proto-Oncogene Proteins p21(ras)--biosynthesis
RNA Interference
RNA, Small Interfering
S-Phase Kinase-Associated Proteins--biosynthesis
Up-Regulation
beta-Galactosidase--biosynthesis