Water channel in the binding site of a high affinity anti-methotrexate antibody. [electronic resource]
Producer: 20140902Description: 3719-26 p. digitalISSN:- 1520-4995
- Animals
- Antibodies, Monoclonal -- chemistry
- Antibody Affinity
- Antimetabolites, Antineoplastic -- chemistry
- Binding Sites, Antibody
- Complementarity Determining Regions -- chemistry
- Crystallography, X-Ray
- Folic Acid Antagonists -- chemistry
- Hybridomas
- Hydrogen Bonding
- Immunoglobulin Fab Fragments -- chemistry
- Immunosuppressive Agents -- antagonists & inhibitors
- Ligands
- Methotrexate -- antagonists & inhibitors
- Mice
- Models, Molecular
- Protein Stability
- Recombinant Proteins -- chemistry
- Thermodynamics
- Water -- chemistry
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Publication Type: Journal Article
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