Water channel in the binding site of a high affinity anti-methotrexate antibody.

Gayda, Susan

Water channel in the binding site of a high affinity anti-methotrexate antibody. [electronic resource] - Biochemistry Jun 2014 - 3719-26 p. digital

Publication Type: Journal Article

1520-4995

10.1021/bi5001382 doi


Animals
Antibodies, Monoclonal--chemistry
Antibody Affinity
Antimetabolites, Antineoplastic--chemistry
Binding Sites, Antibody
Complementarity Determining Regions--chemistry
Crystallography, X-Ray
Folic Acid Antagonists--chemistry
Hybridomas
Hydrogen Bonding
Immunoglobulin Fab Fragments--chemistry
Immunosuppressive Agents--antagonists & inhibitors
Ligands
Methotrexate--antagonists & inhibitors
Mice
Models, Molecular
Protein Stability
Recombinant Proteins--chemistry
Thermodynamics
Water--chemistry