JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis. [electronic resource]
Producer: 20151026Description: 1763-71 p. digitalISSN:- 1468-2060
- Adult
- Aged
- Arthritis, Rheumatoid -- genetics
- Cell Cycle Proteins
- Cell Survival
- Down-Regulation -- drug effects
- Female
- Fibroblasts -- metabolism
- Forkhead Box Protein O1
- Forkhead Box Protein O3
- Forkhead Transcription Factors -- drug effects
- Humans
- Interleukin-1beta -- pharmacology
- Interleukin-6 -- metabolism
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Male
- Middle Aged
- Proto-Oncogene Proteins c-akt -- metabolism
- RNA, Messenger -- metabolism
- Synovial Membrane -- cytology
- Transcription Factors -- genetics
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Journal Article
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