JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis.

Grabiec, Aleksander M

JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis. [electronic resource] - Annals of the rheumatic diseases Sep 2015 - 1763-71 p. digital

Publication Type: Journal Article

1468-2060

10.1136/annrheumdis-2013-203610 doi


Adult
Aged
Arthritis, Rheumatoid--genetics
Cell Cycle Proteins
Cell Survival
Down-Regulation--drug effects
Female
Fibroblasts--metabolism
Forkhead Box Protein O1
Forkhead Box Protein O3
Forkhead Transcription Factors--drug effects
Humans
Interleukin-1beta--pharmacology
Interleukin-6--metabolism
JNK Mitogen-Activated Protein Kinases--metabolism
Male
Middle Aged
Proto-Oncogene Proteins c-akt--metabolism
RNA, Messenger--metabolism
Synovial Membrane--cytology
Transcription Factors--genetics
Tumor Necrosis Factor-alpha--pharmacology