Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation. [electronic resource]
Producer: 20141021Description: e1209 p. digitalISSN:- 2041-4889
- AMP-Activated Protein Kinases -- metabolism
- Animals
- Dose-Response Relationship, Drug
- Down-Regulation
- Enzyme Activation
- Gestational Age
- HeLa Cells
- Hippocampus -- drug effects
- Humans
- Hypoglycemic Agents -- pharmacology
- Metformin -- pharmacology
- Mice
- Mice, Inbred C57BL
- Neurons -- drug effects
- Phosphorylation
- Primary Cell Culture
- Protein Kinase Inhibitors -- pharmacology
- Protein Phosphatase 2 -- metabolism
- Serine
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Time Factors
- Transfection
- alpha-Synuclein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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