Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.

Pérez-Revuelta, B I

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation. [electronic resource] - Cell death & disease May 2014 - e1209 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/cddis.2014.175 doi


AMP-Activated Protein Kinases--metabolism
Animals
Dose-Response Relationship, Drug
Down-Regulation
Enzyme Activation
Gestational Age
HeLa Cells
Hippocampus--drug effects
Humans
Hypoglycemic Agents--pharmacology
Metformin--pharmacology
Mice
Mice, Inbred C57BL
Neurons--drug effects
Phosphorylation
Primary Cell Culture
Protein Kinase Inhibitors--pharmacology
Protein Phosphatase 2--metabolism
Serine
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--antagonists & inhibitors
Time Factors
Transfection
alpha-Synuclein--genetics