Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor. [electronic resource]
Producer: 20150804Description: 3814 p. digitalISSN:- 2041-1723
- Amino Acid Sequence
- Animals
- Apoptosis -- genetics
- Cell Cycle Checkpoints -- genetics
- Cell Cycle Proteins
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Crystallography, X-Ray
- Female
- HCT116 Cells
- Humans
- Leucine Zippers -- genetics
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Molecular Dynamics Simulation
- Multiprotein Complexes -- ultrastructure
- Neoplasm Transplantation
- Neoplasms -- drug therapy
- Nuclear Proteins -- antagonists & inhibitors
- Protein Engineering
- Protein Structure, Tertiary
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Recombinant Proteins -- pharmacology
- Sequence Alignment
- Transplantation, Heterologous
- Tumor Suppressor Protein p53 -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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