Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor.

Lee, Jung-Hoon

Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor. [electronic resource] - Nature communications May 2014 - 3814 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-1723

10.1038/ncomms4814 doi


Amino Acid Sequence
Animals
Apoptosis--genetics
Cell Cycle Checkpoints--genetics
Cell Cycle Proteins
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Crystallography, X-Ray
Female
HCT116 Cells
Humans
Leucine Zippers--genetics
Mice
Mice, Inbred BALB C
Mice, Nude
Molecular Dynamics Simulation
Multiprotein Complexes--ultrastructure
Neoplasm Transplantation
Neoplasms--drug therapy
Nuclear Proteins--antagonists & inhibitors
Protein Engineering
Protein Structure, Tertiary
Proto-Oncogene Proteins--antagonists & inhibitors
Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors
Recombinant Proteins--pharmacology
Sequence Alignment
Transplantation, Heterologous
Tumor Suppressor Protein p53--chemistry