Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells. [electronic resource]
Producer: 20150219Description: 2678-87 p. digitalISSN:- 1949-2553
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- BRCA1 Protein -- metabolism
- Benzoquinones -- pharmacology
- Blotting, Western
- Breast Neoplasms -- drug therapy
- Carboplatin -- administration & dosage
- Carcinoma, Ovarian Epithelial
- Drug Resistance, Neoplasm -- drug effects
- Enzyme Inhibitors -- pharmacology
- Female
- Flow Cytometry
- Fluorescent Antibody Technique
- Humans
- Immunoenzyme Techniques
- Lactams, Macrocyclic -- pharmacology
- Neoplasms, Glandular and Epithelial -- drug therapy
- Ovarian Neoplasms -- drug therapy
- Phthalazines -- administration & dosage
- Piperazines -- administration & dosage
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- metabolism
- Recombinational DNA Repair -- drug effects
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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