Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells.

Choi, Young Eun

Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells. [electronic resource] - Oncotarget May 2014 - 2678-87 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1949-2553

10.18632/oncotarget.1929 doi


Antineoplastic Combined Chemotherapy Protocols--pharmacology
BRCA1 Protein--metabolism
Benzoquinones--pharmacology
Blotting, Western
Breast Neoplasms--drug therapy
Carboplatin--administration & dosage
Carcinoma, Ovarian Epithelial
Drug Resistance, Neoplasm--drug effects
Enzyme Inhibitors--pharmacology
Female
Flow Cytometry
Fluorescent Antibody Technique
Humans
Immunoenzyme Techniques
Lactams, Macrocyclic--pharmacology
Neoplasms, Glandular and Epithelial--drug therapy
Ovarian Neoplasms--drug therapy
Phthalazines--administration & dosage
Piperazines--administration & dosage
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases--metabolism
Recombinational DNA Repair--drug effects
Tumor Cells, Cultured