Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers. [electronic resource]
Producer: 20140828Description: 3146-56 p. digitalISSN:- 1538-7445
- Animals
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Line, Tumor
- Humans
- Lung Neoplasms -- drug therapy
- MAP Kinase Signaling System -- drug effects
- Mice
- Mice, Nude
- Mitochondria -- drug effects
- Mutation
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Signal Transduction -- drug effects
- bcl-X Protein -- genetics
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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