Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.

Hata, Aaron N

Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers. [electronic resource] - Cancer research Jun 2014 - 3146-56 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1538-7445

10.1158/0008-5472.CAN-13-3728 doi


Animals
Apoptosis--drug effects
Apoptosis Regulatory Proteins--genetics
Carcinoma, Non-Small-Cell Lung--drug therapy
Cell Line, Tumor
Humans
Lung Neoplasms--drug therapy
MAP Kinase Signaling System--drug effects
Mice
Mice, Nude
Mitochondria--drug effects
Mutation
Phosphatidylinositol 3-Kinases--genetics
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-bcl-2--genetics
Signal Transduction--drug effects
bcl-X Protein--genetics
ras Proteins--genetics