Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation. [electronic resource]
Producer: 20141028Description: 3508-22 p. digitalISSN:- 1420-3049
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Carcinoma, Non-Small-Cell Lung -- metabolism
- Caspases -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Gefitinib
- HSP90 Heat-Shock Proteins -- metabolism
- Humans
- Inhibitory Concentration 50
- Lung Neoplasms -- metabolism
- Mitochondria -- drug effects
- Pentacyclic Triterpenes
- Protein Kinase Inhibitors -- pharmacology
- Proteolysis -- drug effects
- Quinazolines -- pharmacology
- Signal Transduction -- drug effects
- Triterpenes -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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