Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.
Fan, Xing-Xing
Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation. [electronic resource] - Molecules (Basel, Switzerland) Mar 2014 - 3508-22 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1420-3049
10.3390/molecules19033508 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Carcinoma, Non-Small-Cell Lung--metabolism
Caspases--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
Gefitinib
HSP90 Heat-Shock Proteins--metabolism
Humans
Inhibitory Concentration 50
Lung Neoplasms--metabolism
Mitochondria--drug effects
Pentacyclic Triterpenes
Protein Kinase Inhibitors--pharmacology
Proteolysis--drug effects
Quinazolines--pharmacology
Signal Transduction--drug effects
Triterpenes--pharmacology
Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation. [electronic resource] - Molecules (Basel, Switzerland) Mar 2014 - 3508-22 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1420-3049
10.3390/molecules19033508 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Carcinoma, Non-Small-Cell Lung--metabolism
Caspases--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
Gefitinib
HSP90 Heat-Shock Proteins--metabolism
Humans
Inhibitory Concentration 50
Lung Neoplasms--metabolism
Mitochondria--drug effects
Pentacyclic Triterpenes
Protein Kinase Inhibitors--pharmacology
Proteolysis--drug effects
Quinazolines--pharmacology
Signal Transduction--drug effects
Triterpenes--pharmacology