Phytoestrogen, tanshinone IIA diminishes collagen deposition and stimulates new elastogenesis in cultures of human cardiac fibroblasts. [electronic resource]
Producer: 20140605Description: 189-197 p. digitalISSN:- 1090-2422
- Abietanes -- pharmacology
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Cell Line
- Collagen Type I -- genetics
- Cyclic AMP Response Element-Binding Protein -- metabolism
- Cyclic AMP-Dependent Protein Kinases -- metabolism
- Down-Regulation
- Elastic Tissue -- metabolism
- Elastin -- genetics
- Enzyme Activation -- drug effects
- Extracellular Matrix -- metabolism
- Humans
- Matrix Metalloproteinase 1 -- biosynthesis
- Matrix Metalloproteinase 2 -- biosynthesis
- Matrix Metalloproteinase 9 -- biosynthesis
- Myocardial Infarction -- metabolism
- Myocardium
- Myocytes, Cardiac -- drug effects
- Phosphorylation -- drug effects
- Phytoestrogens -- pharmacology
- Protein Binding -- drug effects
- Protein-Lysine 6-Oxidase -- biosynthesis
- Receptors, Estrogen -- metabolism
- Receptors, G-Protein-Coupled -- metabolism
- Tropoelastin -- metabolism
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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