Phytoestrogen, tanshinone IIA diminishes collagen deposition and stimulates new elastogenesis in cultures of human cardiac fibroblasts.

Mao, Shuai

Phytoestrogen, tanshinone IIA diminishes collagen deposition and stimulates new elastogenesis in cultures of human cardiac fibroblasts. [electronic resource] - Experimental cell research Apr 2014 - 189-197 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1090-2422

10.1016/j.yexcr.2014.02.001 doi


Abietanes--pharmacology
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Cell Line
Collagen Type I--genetics
Cyclic AMP Response Element-Binding Protein--metabolism
Cyclic AMP-Dependent Protein Kinases--metabolism
Down-Regulation
Elastic Tissue--metabolism
Elastin--genetics
Enzyme Activation--drug effects
Extracellular Matrix--metabolism
Humans
Matrix Metalloproteinase 1--biosynthesis
Matrix Metalloproteinase 2--biosynthesis
Matrix Metalloproteinase 9--biosynthesis
Myocardial Infarction--metabolism
Myocardium
Myocytes, Cardiac--drug effects
Phosphorylation--drug effects
Phytoestrogens--pharmacology
Protein Binding--drug effects
Protein-Lysine 6-Oxidase--biosynthesis
Receptors, Estrogen--metabolism
Receptors, G-Protein-Coupled--metabolism
Tropoelastin--metabolism
Up-Regulation