Inactivation of Apaf1 reduces the formation of mutant huntingtin-dependent aggregates and cell death. [electronic resource]
Producer: 20141124Description: 83-91 p. digitalISSN:- 1873-7544
- Animals
- Apoptosis -- drug effects
- Apoptotic Protease-Activating Factor 1 -- antagonists & inhibitors
- Cell Line
- Cell Survival -- drug effects
- Cells, Cultured
- Corpus Striatum -- drug effects
- Fibroblasts
- HSP70 Heat-Shock Proteins -- metabolism
- HeLa Cells
- Heterocyclic Compounds -- pharmacology
- Humans
- Huntingtin Protein
- Huntington Disease -- drug therapy
- Mice
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Nerve Tissue Proteins -- genetics
- Nuclear Proteins -- genetics
- Peptides -- metabolism
- Serotonin Plasma Membrane Transport Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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