Inactivation of Apaf1 reduces the formation of mutant huntingtin-dependent aggregates and cell death.
Sancho, M
Inactivation of Apaf1 reduces the formation of mutant huntingtin-dependent aggregates and cell death. [electronic resource] - Neuroscience Mar 2014 - 83-91 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1873-7544
10.1016/j.neuroscience.2013.12.062 doi
Animals
Apoptosis--drug effects
Apoptotic Protease-Activating Factor 1--antagonists & inhibitors
Cell Line
Cell Survival--drug effects
Cells, Cultured
Corpus Striatum--drug effects
Fibroblasts
HSP70 Heat-Shock Proteins--metabolism
HeLa Cells
Heterocyclic Compounds--pharmacology
Humans
Huntingtin Protein
Huntington Disease--drug therapy
Mice
Mice, Knockout
Mice, Transgenic
Mutation
Nerve Tissue Proteins--genetics
Nuclear Proteins--genetics
Peptides--metabolism
Serotonin Plasma Membrane Transport Proteins--metabolism
Inactivation of Apaf1 reduces the formation of mutant huntingtin-dependent aggregates and cell death. [electronic resource] - Neuroscience Mar 2014 - 83-91 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1873-7544
10.1016/j.neuroscience.2013.12.062 doi
Animals
Apoptosis--drug effects
Apoptotic Protease-Activating Factor 1--antagonists & inhibitors
Cell Line
Cell Survival--drug effects
Cells, Cultured
Corpus Striatum--drug effects
Fibroblasts
HSP70 Heat-Shock Proteins--metabolism
HeLa Cells
Heterocyclic Compounds--pharmacology
Humans
Huntingtin Protein
Huntington Disease--drug therapy
Mice
Mice, Knockout
Mice, Transgenic
Mutation
Nerve Tissue Proteins--genetics
Nuclear Proteins--genetics
Peptides--metabolism
Serotonin Plasma Membrane Transport Proteins--metabolism