Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. [electronic resource]
Producer: 20140826Description: 523-35 p. digitalISSN:- 1476-5381
- Acetylation
- Adenylate Kinase -- metabolism
- Animals
- Apoptosis -- drug effects
- Blotting, Western
- Capillaries -- cytology
- Cellular Senescence -- drug effects
- Diabetes Mellitus, Type 2 -- genetics
- Endothelium, Vascular -- drug effects
- Fluorescent Antibody Technique
- Forkhead Box Protein O1
- Forkhead Transcription Factors -- metabolism
- Gene Silencing
- Hyperglycemia -- physiopathology
- Hypoglycemic Agents -- pharmacology
- Metformin -- pharmacology
- Mice
- Mice, Inbred C57BL
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Sirtuin 1 -- genetics
- beta-Galactosidase -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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