Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1.

Arunachalam, Gnanapragasam

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. [electronic resource] - British journal of pharmacology Jan 2014 - 523-35 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5381

10.1111/bph.12496 doi


Acetylation
Adenylate Kinase--metabolism
Animals
Apoptosis--drug effects
Blotting, Western
Capillaries--cytology
Cellular Senescence--drug effects
Diabetes Mellitus, Type 2--genetics
Endothelium, Vascular--drug effects
Fluorescent Antibody Technique
Forkhead Box Protein O1
Forkhead Transcription Factors--metabolism
Gene Silencing
Hyperglycemia--physiopathology
Hypoglycemic Agents--pharmacology
Metformin--pharmacology
Mice
Mice, Inbred C57BL
Reactive Oxygen Species--metabolism
Signal Transduction--drug effects
Sirtuin 1--genetics
beta-Galactosidase--metabolism