Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA. [electronic resource]
Producer: 20140218Description: 6281-91 p. digitalISSN:- 1550-6606
- Active Transport, Cell Nucleus -- drug effects
- Adaptor Proteins, Signal Transducing
- Antineoplastic Agents, Alkylating -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- biosynthesis
- B-Lymphocytes -- cytology
- Caspases -- metabolism
- Cell Transformation, Viral
- Cells, Cultured
- DNA-Binding Proteins -- biosynthesis
- Enzyme Activation -- drug effects
- Gene Expression Regulation -- drug effects
- Herpesvirus 4, Human -- physiology
- Humans
- Imidazoles -- pharmacology
- Intracellular Signaling Peptides and Proteins -- biosynthesis
- Melphalan -- pharmacology
- Mitochondria -- metabolism
- Neoplasm Proteins -- biosynthesis
- Nuclear Proteins -- biosynthesis
- Oxidative Stress
- Phosphorylation -- drug effects
- Proline -- analogs & derivatives
- Protein Interaction Mapping
- Protein Isoforms -- physiology
- Protein Processing, Post-Translational -- drug effects
- Protein Structure, Tertiary
- Proto-Oncogene Proteins -- biosynthesis
- Pyridines -- pharmacology
- RNA Interference
- RNA, Small Interfering -- pharmacology
- Reactive Oxygen Species -- metabolism
- Transcriptional Activation
- Tumor Protein p73
- Tumor Suppressor Proteins -- biosynthesis
- Xeroderma Pigmentosum Group A Protein -- metabolism
- bcl-2-Associated X Protein -- metabolism
- p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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