Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA.

Park, Ga Bin

Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Dec 2013 - 6281-91 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1550-6606

10.4049/jimmunol.1203442 doi


Active Transport, Cell Nucleus--drug effects
Adaptor Proteins, Signal Transducing
Antineoplastic Agents, Alkylating--pharmacology
Apoptosis--drug effects
Apoptosis Regulatory Proteins--biosynthesis
B-Lymphocytes--cytology
Caspases--metabolism
Cell Transformation, Viral
Cells, Cultured
DNA-Binding Proteins--biosynthesis
Enzyme Activation--drug effects
Gene Expression Regulation--drug effects
Herpesvirus 4, Human--physiology
Humans
Imidazoles--pharmacology
Intracellular Signaling Peptides and Proteins--biosynthesis
Melphalan--pharmacology
Mitochondria--metabolism
Neoplasm Proteins--biosynthesis
Nuclear Proteins--biosynthesis
Oxidative Stress
Phosphorylation--drug effects
Proline--analogs & derivatives
Protein Interaction Mapping
Protein Isoforms--physiology
Protein Processing, Post-Translational--drug effects
Protein Structure, Tertiary
Proto-Oncogene Proteins--biosynthesis
Pyridines--pharmacology
RNA Interference
RNA, Small Interfering--pharmacology
Reactive Oxygen Species--metabolism
Transcriptional Activation
Tumor Protein p73
Tumor Suppressor Proteins--biosynthesis
Xeroderma Pigmentosum Group A Protein--metabolism
bcl-2-Associated X Protein--metabolism
p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors