Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. [electronic resource]
Producer: 20140106Description: 18161-74 p. digitalISSN:- 1529-2401
- ADAM Proteins -- metabolism
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Animals
- Autoantibodies -- blood
- COS Cells
- Child
- Child, Preschool
- Chlorocebus aethiops
- Epilepsy -- blood
- Female
- HEK293 Cells
- Humans
- Infant
- Intracellular Signaling Peptides and Proteins
- Limbic Encephalitis -- blood
- Male
- Mice
- Mice, Knockout
- Middle Aged
- Nerve Tissue Proteins -- metabolism
- Protein Binding -- physiology
- Proteins -- metabolism
- Rats
- Receptors, AMPA -- metabolism
- Young Adult
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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