Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors.

Ohkawa, Toshika

Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Nov 2013 - 18161-74 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.3506-13.2013 doi


ADAM Proteins--metabolism
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Autoantibodies--blood
COS Cells
Child
Child, Preschool
Chlorocebus aethiops
Epilepsy--blood
Female
HEK293 Cells
Humans
Infant
Intracellular Signaling Peptides and Proteins
Limbic Encephalitis--blood
Male
Mice
Mice, Knockout
Middle Aged
Nerve Tissue Proteins--metabolism
Protein Binding--physiology
Proteins--metabolism
Rats
Receptors, AMPA--metabolism
Young Adult