An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase. [electronic resource]
Producer: 20140919Description: 649-60 p. digitalISSN:- 1768-3254
- Androstenes -- chemical synthesis
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclization
- Dehydration
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Enzyme Inhibitors -- chemical synthesis
- HeLa Cells
- Humans
- MCF-7 Cells
- Male
- Molecular Conformation
- Oximes -- chemistry
- Rats
- Rats, Wistar
- Steroid 17-alpha-Hydroxylase -- antagonists & inhibitors
- Structure-Activity Relationship
- Testis -- enzymology
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
There are no comments on this title.
Log in to your account to post a comment.