An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase.
Kovács, Dóra
An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase. [electronic resource] - European journal of medicinal chemistry 2013 - 649-60 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1768-3254
10.1016/j.ejmech.2013.10.038 doi
Androstenes--chemical synthesis
Animals
Antineoplastic Agents--chemical synthesis
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclization
Dehydration
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors--chemical synthesis
HeLa Cells
Humans
MCF-7 Cells
Male
Molecular Conformation
Oximes--chemistry
Rats
Rats, Wistar
Steroid 17-alpha-Hydroxylase--antagonists & inhibitors
Structure-Activity Relationship
Testis--enzymology
An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase. [electronic resource] - European journal of medicinal chemistry 2013 - 649-60 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1768-3254
10.1016/j.ejmech.2013.10.038 doi
Androstenes--chemical synthesis
Animals
Antineoplastic Agents--chemical synthesis
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclization
Dehydration
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors--chemical synthesis
HeLa Cells
Humans
MCF-7 Cells
Male
Molecular Conformation
Oximes--chemistry
Rats
Rats, Wistar
Steroid 17-alpha-Hydroxylase--antagonists & inhibitors
Structure-Activity Relationship
Testis--enzymology