The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. [electronic resource]
Producer: 20141228Description: 570-8 p. digitalISSN:- 1366-5928
- Animals
- Blotting, Western
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Fibrosis
- Gene Expression Regulation -- drug effects
- Inflammation -- pathology
- Intracellular Signaling Peptides and Proteins -- metabolism
- Kelch-Like ECH-Associated Protein 1
- Kidney -- drug effects
- Male
- NF-E2-Related Factor 2 -- metabolism
- Oleanolic Acid -- analogs & derivatives
- Oxidative Stress -- drug effects
- RNA, Messenger -- genetics
- Rats, Sprague-Dawley
- Renal Insufficiency, Chronic -- drug therapy
- Signal Transduction -- drug effects
- Smad7 Protein -- metabolism
- Transforming Growth Factor beta -- metabolism
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Publication Type: Journal Article
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