The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.

Aminzadeh, Mohammad A

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. [electronic resource] - Xenobiotica; the fate of foreign compounds in biological systems Jun 2014 - 570-8 p. digital

Publication Type: Journal Article

1366-5928

10.3109/00498254.2013.852705 doi


Animals
Blotting, Western
Extracellular Signal-Regulated MAP Kinases--metabolism
Fibrosis
Gene Expression Regulation--drug effects
Inflammation--pathology
Intracellular Signaling Peptides and Proteins--metabolism
Kelch-Like ECH-Associated Protein 1
Kidney--drug effects
Male
NF-E2-Related Factor 2--metabolism
Oleanolic Acid--analogs & derivatives
Oxidative Stress--drug effects
RNA, Messenger--genetics
Rats, Sprague-Dawley
Renal Insufficiency, Chronic--drug therapy
Signal Transduction--drug effects
Smad7 Protein--metabolism
Transforming Growth Factor beta--metabolism