Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. [electronic resource]
Producer: 20140929Description: 179-89 p. digitalISSN:- 1538-8514
- Cell Proliferation -- drug effects
- Colchicine -- administration & dosage
- Colonic Neoplasms -- drug therapy
- HCT116 Cells
- Humans
- Hydrogen Bonding
- Microtubules -- drug effects
- Mitosis -- drug effects
- Molecular Dynamics Simulation
- Protein Conformation -- drug effects
- Thiazoles -- administration & dosage
- Tubulin -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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