Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics.

Thomas, Nisha E

Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. [electronic resource] - Molecular cancer therapeutics Jan 2014 - 179-89 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-8514

10.1158/1535-7163.MCT-13-0479 doi


Cell Proliferation--drug effects
Colchicine--administration & dosage
Colonic Neoplasms--drug therapy
HCT116 Cells
Humans
Hydrogen Bonding
Microtubules--drug effects
Mitosis--drug effects
Molecular Dynamics Simulation
Protein Conformation--drug effects
Thiazoles--administration & dosage
Tubulin--chemistry