Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. [electronic resource]
Producer: 20140310Description: 8032-48 p. digitalISSN:- 1520-4804
- Administration, Oral
- Animals
- Area Under Curve
- Biological Availability
- Blood-Brain Barrier -- metabolism
- Brain -- metabolism
- Carbazoles -- chemical synthesis
- Cells, Cultured
- Cognition Disorders -- complications
- Drug Discovery -- methods
- HIV Infections -- complications
- Humans
- JNK Mitogen-Activated Protein Kinases -- metabolism
- MAP Kinase Kinase Kinases -- antagonists & inhibitors
- Male
- Mice
- Mice, Inbred C57BL
- Models, Chemical
- Molecular Structure
- Monocytes -- drug effects
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- chemical synthesis
- Pyridines -- chemical synthesis
- Pyrroles -- chemical synthesis
- Tumor Necrosis Factor-alpha -- metabolism
- tat Gene Products, Human Immunodeficiency Virus -- pharmacology
- Mitogen-Activated Protein Kinase Kinase Kinase 11
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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