Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

Goodfellow, Val S

Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. [electronic resource] - Journal of medicinal chemistry Oct 2013 - 8032-48 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm401094t doi


Administration, Oral
Animals
Area Under Curve
Biological Availability
Blood-Brain Barrier--metabolism
Brain--metabolism
Carbazoles--chemical synthesis
Cells, Cultured
Cognition Disorders--complications
Drug Discovery--methods
HIV Infections--complications
Humans
JNK Mitogen-Activated Protein Kinases--metabolism
MAP Kinase Kinase Kinases--antagonists & inhibitors
Male
Mice
Mice, Inbred C57BL
Models, Chemical
Molecular Structure
Monocytes--drug effects
Phosphorylation--drug effects
Protein Kinase Inhibitors--chemical synthesis
Pyridines--chemical synthesis
Pyrroles--chemical synthesis
Tumor Necrosis Factor-alpha--metabolism
tat Gene Products, Human Immunodeficiency Virus--pharmacology
Mitogen-Activated Protein Kinase Kinase Kinase 11