Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine. [electronic resource]
Producer: 20140408Description: e70798 p. digitalISSN:- 1932-6203
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Click Chemistry
- DNA Fragmentation -- drug effects
- DNA, Neoplasm -- antagonists & inhibitors
- G-Quadruplexes -- drug effects
- Humans
- Ligands
- Melanoma, Experimental -- chemistry
- Mice
- Mice, Inbred C57BL
- Skin Neoplasms -- chemistry
- Thymidine -- chemistry
- Triazoles -- chemistry
- Tumor Burden -- drug effects
- Zidovudine -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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