Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.
Mahesh Kumar, Jerald
Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine. [electronic resource] - PloS one 2013 - e70798 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0070798 doi
Animals
Antineoplastic Agents--chemical synthesis
Cell Line, Tumor
Cell Proliferation--drug effects
Click Chemistry
DNA Fragmentation--drug effects
DNA, Neoplasm--antagonists & inhibitors
G-Quadruplexes--drug effects
Humans
Ligands
Melanoma, Experimental--chemistry
Mice
Mice, Inbred C57BL
Skin Neoplasms--chemistry
Thymidine--chemistry
Triazoles--chemistry
Tumor Burden--drug effects
Zidovudine--chemistry
Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine. [electronic resource] - PloS one 2013 - e70798 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0070798 doi
Animals
Antineoplastic Agents--chemical synthesis
Cell Line, Tumor
Cell Proliferation--drug effects
Click Chemistry
DNA Fragmentation--drug effects
DNA, Neoplasm--antagonists & inhibitors
G-Quadruplexes--drug effects
Humans
Ligands
Melanoma, Experimental--chemistry
Mice
Mice, Inbred C57BL
Skin Neoplasms--chemistry
Thymidine--chemistry
Triazoles--chemistry
Tumor Burden--drug effects
Zidovudine--chemistry