Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. [electronic resource]
Producer: 20131104Description: E2987-96 p. digitalISSN:- 1091-6490
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal -- chemistry
- Antibodies, Monoclonal, Humanized -- chemistry
- Antineoplastic Agents -- chemistry
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Crystallography, X-Ray
- Drug Design
- Hepatocyte Growth Factor -- chemistry
- Humans
- Immunoglobulin Fab Fragments -- chemistry
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Nude
- Mice, SCID
- Mice, Transgenic
- Models, Molecular
- Molecular Sequence Data
- Neoplasms -- drug therapy
- Protein Binding -- drug effects
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-met -- antagonists & inhibitors
- Sequence Homology, Amino Acid
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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