The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo. [electronic resource]
Producer: 20140205Description: e66388 p. digitalISSN:- 1932-6203
- Acetylcysteine -- pharmacology
- Animals
- Antineoplastic Agents -- pharmacology
- Antioxidants -- pharmacology
- Apoptosis -- drug effects
- Carcinogenesis
- Cell Hypoxia
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Drug Screening Assays, Antitumor
- Epithelial-Mesenchymal Transition
- Female
- Glutathione -- blood
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Lung Neoplasms -- blood supply
- Mammary Neoplasms, Experimental -- blood supply
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Neoplasm Transplantation
- Neovascularization, Pathologic -- metabolism
- Phenotype
- Protein Stability
- Tumor Burden -- drug effects
- Vascular Endothelial Growth Factor A -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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