The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo.

Sceneay, Jaclyn

The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo. [electronic resource] - PloS one 2013 - e66388 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0066388 doi


Acetylcysteine--pharmacology
Animals
Antineoplastic Agents--pharmacology
Antioxidants--pharmacology
Apoptosis--drug effects
Carcinogenesis
Cell Hypoxia
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Screening Assays, Antitumor
Epithelial-Mesenchymal Transition
Female
Glutathione--blood
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Lung Neoplasms--blood supply
Mammary Neoplasms, Experimental--blood supply
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Neoplasm Transplantation
Neovascularization, Pathologic--metabolism
Phenotype
Protein Stability
Tumor Burden--drug effects
Vascular Endothelial Growth Factor A--metabolism