Herpes simplex virus 1-encoded tegument protein VP16 abrogates the production of beta interferon (IFN) by inhibiting NF-κB activation and blocking IFN regulatory factor 3 to recruit its coactivator CBP. [electronic resource]
Producer: 20131125Description: 9788-801 p. digitalISSN:- 1098-5514
- Animals
- CREB-Binding Protein -- metabolism
- Chlorocebus aethiops
- HEK293 Cells
- HeLa Cells
- Herpes Simplex Virus Protein Vmw65 -- chemistry
- Herpesvirus 1, Human -- genetics
- Host-Pathogen Interactions -- genetics
- Humans
- Immunity, Innate
- Interferon Regulatory Factor-3 -- antagonists & inhibitors
- Interferon Regulatory Factor-7 -- metabolism
- Interferon-beta -- biosynthesis
- Promoter Regions, Genetic
- Protein Structure, Tertiary
- Sendai virus -- immunology
- Transcription Factor RelA -- antagonists & inhibitors
- Transcriptional Activation
- Vero Cells
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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