Herpes simplex virus 1-encoded tegument protein VP16 abrogates the production of beta interferon (IFN) by inhibiting NF-κB activation and blocking IFN regulatory factor 3 to recruit its coactivator CBP.

Xing, Junji

Herpes simplex virus 1-encoded tegument protein VP16 abrogates the production of beta interferon (IFN) by inhibiting NF-κB activation and blocking IFN regulatory factor 3 to recruit its coactivator CBP. [electronic resource] - Journal of virology Sep 2013 - 9788-801 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1098-5514

10.1128/JVI.01440-13 doi


Animals
CREB-Binding Protein--metabolism
Chlorocebus aethiops
HEK293 Cells
HeLa Cells
Herpes Simplex Virus Protein Vmw65--chemistry
Herpesvirus 1, Human--genetics
Host-Pathogen Interactions--genetics
Humans
Immunity, Innate
Interferon Regulatory Factor-3--antagonists & inhibitors
Interferon Regulatory Factor-7--metabolism
Interferon-beta--biosynthesis
Promoter Regions, Genetic
Protein Structure, Tertiary
Sendai virus--immunology
Transcription Factor RelA--antagonists & inhibitors
Transcriptional Activation
Vero Cells