Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance. [electronic resource]
Producer: 20130828Description: 104-12 p. digitalISSN:- 1872-9142
- Adaptor Proteins, Signal Transducing -- genetics
- Antibodies, Monoclonal, Humanized -- pharmacology
- Blotting, Western
- Breast Neoplasms -- genetics
- Cell Culture Techniques
- Cell Line
- Cell Line, Tumor
- Cell Movement -- genetics
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Down-Regulation
- Drug Resistance, Neoplasm -- genetics
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Indazoles -- pharmacology
- MCF-7 Cells
- Neuregulin-1 -- pharmacology
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- RNA Interference
- Receptor, ErbB-2 -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Sulfonamides -- pharmacology
- Trastuzumab
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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