Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance.

Liu, Dan

Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance. [electronic resource] - Molecular immunology Nov 2013 - 104-12 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1872-9142

10.1016/j.molimm.2013.04.007 doi


Adaptor Proteins, Signal Transducing--genetics
Antibodies, Monoclonal, Humanized--pharmacology
Blotting, Western
Breast Neoplasms--genetics
Cell Culture Techniques
Cell Line
Cell Line, Tumor
Cell Movement--genetics
Cell Survival--drug effects
Dose-Response Relationship, Drug
Down-Regulation
Drug Resistance, Neoplasm--genetics
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Indazoles--pharmacology
MCF-7 Cells
Neuregulin-1--pharmacology
Phosphorylation--drug effects
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
RNA Interference
Receptor, ErbB-2--genetics
Reverse Transcriptase Polymerase Chain Reaction
Sulfonamides--pharmacology
Trastuzumab