Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis. [electronic resource]
Producer: 20140506Description: 261-73 p. digitalISSN:- 1879-0712
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Carcinoma, Hepatocellular -- blood supply
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Enzyme Activation -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Liver Neoplasms -- blood supply
- MAP Kinase Signaling System -- drug effects
- Matrix Metalloproteinase 2 -- metabolism
- Matrix Metalloproteinase 9 -- metabolism
- Mice
- Mice, Nude
- Neoplasm Invasiveness
- Neovascularization, Pathologic -- drug therapy
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Saponins -- pharmacology
- TOR Serine-Threonine Kinases -- metabolism
- Vascular Endothelial Growth Factor A -- pharmacology
- Vascular Endothelial Growth Factor Receptor-2 -- metabolism
- Xenograft Model Antitumor Assays
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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