Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis.

Zeng, Ke-Wu

Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis. [electronic resource] - European journal of pharmacology Aug 2013 - 261-73 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-0712

10.1016/j.ejphar.2013.04.026 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Carcinoma, Hepatocellular--blood supply
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Enzyme Activation--drug effects
Gene Expression Regulation, Neoplastic--drug effects
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Liver Neoplasms--blood supply
MAP Kinase Signaling System--drug effects
Matrix Metalloproteinase 2--metabolism
Matrix Metalloproteinase 9--metabolism
Mice
Mice, Nude
Neoplasm Invasiveness
Neovascularization, Pathologic--drug therapy
Phosphatidylinositol 3-Kinases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Saponins--pharmacology
TOR Serine-Threonine Kinases--metabolism
Vascular Endothelial Growth Factor A--pharmacology
Vascular Endothelial Growth Factor Receptor-2--metabolism
Xenograft Model Antitumor Assays
p38 Mitogen-Activated Protein Kinases--metabolism