EVI1 targets ΔNp63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon cancer cells. [electronic resource]
Producer: 20140211Description: 1568-76 p. digitalISSN:- 1878-5875
- Base Sequence
- Cell Cycle
- Cell Proliferation
- Colonic Neoplasms -- genetics
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- DNA-Binding Proteins -- chemistry
- Down-Regulation -- genetics
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- HCT116 Cells
- HEK293 Cells
- HT29 Cells
- Humans
- MDS1 and EVI1 Complex Locus Protein
- Molecular Sequence Data
- Promoter Regions, Genetic -- genetics
- Protein Binding -- genetics
- Protein Structure, Tertiary
- Proto-Oncogene Mas
- Proto-Oncogenes
- Transcription Factors -- chemistry
- Transcription, Genetic
- Tumor Suppressor Protein p53 -- deficiency
- Tumor Suppressor Proteins -- metabolism
- Up-Regulation -- genetics
- Zinc Fingers
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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