EVI1 targets ΔNp63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon cancer cells.

Nayak, Kasturi Bala

EVI1 targets ΔNp63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon cancer cells. [electronic resource] - The international journal of biochemistry & cell biology Aug 2013 - 1568-76 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1878-5875

10.1016/j.biocel.2013.04.032 doi


Base Sequence
Cell Cycle
Cell Proliferation
Colonic Neoplasms--genetics
Cyclin-Dependent Kinase Inhibitor p21--genetics
DNA-Binding Proteins--chemistry
Down-Regulation--genetics
Gene Expression Regulation, Neoplastic
Gene Silencing
HCT116 Cells
HEK293 Cells
HT29 Cells
Humans
MDS1 and EVI1 Complex Locus Protein
Molecular Sequence Data
Promoter Regions, Genetic--genetics
Protein Binding--genetics
Protein Structure, Tertiary
Proto-Oncogene Mas
Proto-Oncogenes
Transcription Factors--chemistry
Transcription, Genetic
Tumor Suppressor Protein p53--deficiency
Tumor Suppressor Proteins--metabolism
Up-Regulation--genetics
Zinc Fingers