A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. [electronic resource]
Producer: 20131209Description: ra32 p. digitalISSN:- 1937-9145
- Animals
- Apoptosis
- Breast Neoplasms -- drug therapy
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- drug effects
- Female
- Humans
- Imidazoles -- pharmacology
- Immunoblotting
- Lapatinib
- Mice
- Mice, Nude
- Myeloid Cell Leukemia Sequence 1 Protein -- metabolism
- Nuclear Proteins -- metabolism
- Phosphoprotein Phosphatases -- metabolism
- Piperazines -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Quinazolines -- pharmacology
- RNA Interference
- Receptor, ErbB-2 -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Substrate Specificity
- Tumor Suppressor Protein p53 -- genetics
- Tumor Suppressor Proteins
- Ubiquitin-Protein Ligases -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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