A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.

Kurokawa, Manabu

A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. [electronic resource] - Science signaling May 2013 - ra32 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1937-9145

10.1126/scisignal.2003741 doi


Animals
Apoptosis
Breast Neoplasms--drug therapy
Cell Line, Tumor
Drug Resistance, Neoplasm--drug effects
Female
Humans
Imidazoles--pharmacology
Immunoblotting
Lapatinib
Mice
Mice, Nude
Myeloid Cell Leukemia Sequence 1 Protein--metabolism
Nuclear Proteins--metabolism
Phosphoprotein Phosphatases--metabolism
Piperazines--pharmacology
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors
Quinazolines--pharmacology
RNA Interference
Receptor, ErbB-2--antagonists & inhibitors
Signal Transduction--drug effects
Substrate Specificity
Tumor Suppressor Protein p53--genetics
Tumor Suppressor Proteins
Ubiquitin-Protein Ligases--genetics
Xenograft Model Antitumor Assays