Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. [electronic resource]
Producer: 20131126Description: e61532 p. digitalISSN:- 1932-6203
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Cell Line, Tumor
- Cimetidine -- pharmacology
- Drug Synergism
- Female
- Humans
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Mitochondria -- drug effects
- Molecular Targeted Therapy
- Organophosphates -- pharmacology
- Pancreatic Neoplasms -- drug therapy
- Protein Transport -- drug effects
- Reactive Oxygen Species -- metabolism
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Tumor Burden -- drug effects
- Valproic Acid -- analogs & derivatives
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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